Armodafinil Review: Scientifically-based Facts and Subjective Experiences

It is 2020, and everything around the world is going so fast. The changes, the advancements, the breakthroughs, everything! The best part, however, is that we are at an all-time high when it comes to scientific and medical knowledge. We have medications for most, if not all, diseases and illnesses, which were considered fatal if we go back a couple of decades or more. Even mental illnesses and psychological disorders are now recognized by everyone and are treated well, thanks to all the new medications and drugs. 

Among all these drugs, we have some cognitive enhancers, also known as nootropics, which are now more popular than ever. You might have heard about Ritalin, Adderall, Modafinil, or maybe Armodafinil. These are all drugs that enhance cognitive performance and help people with sleep disorders. This review emphasizes Armodafinil, the R-enantiomer based analogue of Modafinil, and they both share the same company that first patented them.

What Is Armodafinil?

Have you noticed the similarities in the names Armodafinil and Modafinil? Well, the only difference is the Armodafinil has an “Ar-” before Modafinil. Modafinil is a racemic compound as it contains (S)-(+)-modafinil and (R)-(−)Modafinil. In chemistry, these are known as enantiomers. You don’t need to get in details about how these compounds work and what is the chemistry behind it. What you need to know is that Armodafinil contains only (R)-(−)Modafinil enantiomer. Probably the reason behind the AR before Modafinil… 

Anyway, as the company that made Modafinil lost the patent, it went forward to develop a new drug with a different chemical structure but similar effects. That is when they came up with Armodafinil. It is an excellent drug for those who suffer from sleep disorders. Moreover, expect cognitive enhancements as well once you consume a healthy dose of Armodafinil.

What is Armodafinil used for?

Armodafinil is the second-most popular substance in the benzhydryl sulfinyl class. Just like Modafinil, its uses extend far beyond its current approved ones. Here are several approved, as well as off-label uses of Armodafinil:

Cognitive enhancement

Similar to Modafinil, Armodafinil enhances your cognitive performance and allows you to remain more mentally active and focus on things much better. It also makes decision making and problem-solving much less complicated for a person. Furthermore, it also greatly improves your memory for a certain period of time.

So, if you are looking for a smart drug that would improve your performance at the office or college, Armodafinil would be perfect for you. Moreover, if you find it a trouble staying awake or face problems as the brain exhausts quickly, this drug can be a great remedy for you.

Narcolepsy and other sleep issues

Narcolepsy is a disease that makes a person sleepy in any relaxing position/situation. Therefore, they sleep almost at any time and anywhere. To help fight against this excessive sleepiness, there have been several drugs developed, and one of the most effective ones is Armodafinil. It prevents excessive daytime sleepiness and allows you to function actively throughout the day without needing to sleep.

Furthermore, Armodafinil is approved for the treatment of shift work sleep disorder, sleep apnea and excessive daytime sleepiness.

Weight loss

Armodafinil does not itself work as a drug that makes you lose weight. However, it allows you to focus more on exercise, ultimately leading towards weight loss. Once you set your goals and diet plans, this drug would make you more motivated to achieve them and eventually lead to a healthier lifestyle. Your mind would only focus on what you want to achieve. You will not get distracted from anything else.


Even though it’s not approved for depression, Armodafinil has been found to be effective in mitigating the cognitive decline associated with this illness. Studies have been conducted regarding its effectiveness and they have yielded positive results, especially in the case of atypical depression. Simply put, Armodafinil helps the depressed person maintain a normal lifestyle and counteract the heavy decrease in mental abilities associated with depression.

Side Effects

Just like all the other drugs out there, Armodafinil comes with some side effects as well. Although, you do not have to worry about it being extremely harmful as it is approved by the FDA, and it is considered a safe drug. Nevertheless, here are some of its side effects that you need to keep in mind.

  • Headaches and nausea are pretty common among people who consume Armodafinil regularly.
  • It can cause dry mouth and dizziness to its consumers.
  • You might have difficulties sleeping as it prevents the consumer from sleeping by keeping the brain active and enhancing cognitive functioning.
  • You might feel more anxious than usual due to its stronger effects.

Some of the more extreme but rare side effects include,

  • Irregular and excessive heartbeat.
  • There can be hallucinations and severe depression.
  • Confusion and agitation.

If you feel any of these extreme side effects, you must go to a doctor or pharmacist as soon as possible.

Modafinil And Armodafinil

By now, if you are already familiar with Modafinil, you must have realized that it shares a lot of similarities with Armodafinil. Well, why wouldn’t it? Both of them are developed by the same company for similar effects. The only minor difference is in the chemical structure of the two and the name, of course. Anyway, let us compare and contrast the two in more detail.


First of all, let us see some of the similarities between the two before we jump into the differences. Due to only a slight variation in the chemical structure, Armodafinil still shares some similarities with Modafinil. Although the extent of those similarities varies, both of them have some similar effects and side effects. Also, a clinical trial in 2011 found no difference in efficacy between the two, as they shared identical benefits.

  • Both of these drugs improve cognitive performance and allow you to improve memory.
  • Both of these drugs enhance your decision making and problem-solving skills.
  • Both of these drugs fight against narcolepsy and allow you to be mentally active throughout the day.
  • Both share similar side effects which include headaches, dizziness, nausea, anxiety, etc.
  • Both are oral tablets.

These were some of the similarities that the two drugs have in common. However, although they have the same side effects, the extent of each side effect varies. For instance, you might have more anxiety and higher chances of insomnia with Admodafinil than with Modafinil. Contrastingly, you might have headaches and nausea more often with Modafinil than with Armodafinil.


Despite all the similarities, there are some very prominent couple of differences between the two too. Take a look at them.

  • There is a huge difference between the price of the two. Armodafinil has an average cost of $225 per 30 tablets, whereas Modafinil sets you back by an average of $718 per 30 pills.
  • Armodafinil is a stronger drug than Modafinil, as it requires a smaller dose to act as efficiently as a larger dose of Modafinil.

And that is about it. These are the significant differences between the two. As far as the benefits are concerned, you get more or less the same from both of these nootropics.

Wrapping it up

In a nutshell, Modafinil and Armodafinil are similar drugs with a slightly different chemical structure, which is the reason for the few differences among the two. If you are confused about which one to buy, try both of them before you settle for one.

Just choose the one that suits you the best. Armodafinil might be the smart drug of choice for many people due to its considerably low price as compared to Modafinil. Anyway, Armodafinil is, without a doubt, a strong drug with exceptional benefits and little side effects.

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