What is Modafinil?
Modafinil is a wakefulness-promoting agent, also known as a eugoreic. The FDA has classified it as a schedule IV prescription drug in the United States. Its low potential for addiction and abuse has granted it a similar status around the world. Doctors prescribe Modafinil to people suffering from excessive sleepiness caused by sleep disorders. The most common ones are narcolepsy, sleep apnea and shift work sleep disorder. Nowadays, many people prefer to buy Modafinil online for off-label uses. Modafinil is also available as an over-the-counter prescription drug as Provigil®. Still, people seldom buy Provigil, as generic Modafinil sold online is much cheaper.
Although Modafinil is prescribed to treat sleep disorders, Modafinil has other off-label uses. Web reports hint that the vast majority of users do not actually suffer from a sleep disorder. It’s common knowledge people generally use Modafinil for cognitive enhancement. Doctors, entrepreneurs, urban professionals, and students are among the most likely to use it.
Generic Modafinil comes in 200mg tablets, whereas most generic Armodafinil tabs contain 150mg. Modafinil and Armodafinil are FDA approved schedule IV prescription drugs. Just like other schedule IV drugs, Armodafinil is safe, safer even than Modafinil. The reason is quite obvious. Armodafinil is the purified version, with stronger effects on focus and clarity.
Modafinil is the most potent smart drug in use today. Students resort to Modafinil to study longer and get better results. Online pharmacies sell generic Modafinil online at dirt-cheap prices. Of course, Modafinil lies somewhat in a grey area. There are some countries where people can buy Modafinil without requiring a prescription. One such country is the UK, as they allow people the right to buy Modafinil online, as long as it’s for personal use. Still, people have been buying Modafinil online for years with no risks at all for the user.
A UK poll has revealed that 1 in 4 students used nootropics at least once in their life. Of Modafinil has always been the first choice. Furthermore, this poll shows that 1 in 5 people have used nootropics to improve focus. Out of those, 44% have mentioned Modafinil as their drug of choice.
Off-label uses of Modafinil
Modafinil is known for its off-label uses which pertain to any purpose not cleared by the FDA. However, off-label use is not exclusively non-medical. People use Modafinil to stay on top of their game and maintain an active lifestyle. This, in turn, leads to emotional well-being and balance in one’s life. Furthermore, doctors are prescribing it as an unofficial treatment for ADHD and depression. This happens because Modafinil is a safer and more effective alternative.
Some off-label uses of Modafinil are widely known, whereas others may come as a surprise to you:
In recent years, education has become more tedious and time-consuming. Caffeine and energy drinks have long been on students’ exam menus. Unfortunately, some addictive and highly toxic stimulants (Adderall or Ritalin) are also popular. Modafinil is obviously the preferred option when it comes to studying. Aside from its safety, it is believed to be more effective when it comes to cognitive enhancement. Furthermore, its lack of euphoria and memory boost also make it a better choice when it comes to studying. Students have also reported an increase in desire to attain knowledge.
Some off-label uses of Modafinil are widely known, whereas others may come as a surprise to you:
● Reduce fatigue
● Improve vigilance
● Increase memory retention
● Improve focus
● Increase motivation and drive
Beware that you need that necessary beauty sleep. Modafinil is definitely not a replacement for proper rest. This study shows that Modafinil enhances centrality. Basically, Modafinil increases the functional network nodes of the primary visual cortex. Subjects consuming Modafinil showed increased connections between the visual cortex and the cerebellum.
A published systematic review co-authored by R. Battleday has identified that Modafinil intensifies cognition. It also concluded that it had very mild side effects compared to its counterparts.
With regards to productivity, Modafinil tops the list among students and professionals alike. The main perks? Laser-like focus, crystal clarity and high degree of wakefulness. By increasing wakefulness, it enhances the ability to concentrate for hours on end. And so you end up retaining more information without feeling tired or drowsy. Increased working memory and problem solving help professionals stay on top of their game. Thus, they can save countless work hours and make the use of time more effectively. In today’s competitive world, time is by far the most valuable asset.
Modafinil also helps in clearing away brain fog and amping up reaction times. A study conducted in 2012 concluded that modafinil enhanced performance on cognition tests. Contestants worked more swiftly while doing work that involved memory and planning.
3. Increased performance
Gym and sports enthusiasts are keen to dose up on Modafinil. That’s because of its capacity to improve endurance, reaction times and strength. Their neural chemistry is more swift which gives them an edge when wanting to push their limits. Body-builders perform better through increased weight-lifting abilities. Also, joggers run faster and longer as a result of better stamina for cardio exercises.
4. Public speaking
When it comes to coming face to face with a large audience, it’s natural to get at least some jitters. Some people experience anxiety, which can lead to stammering or other awkward moments. Modafinil helps by keeping the tension streak under control. It calms your nerves and makes you more receptive and present to the lecture or speech you are going to deliver. A neuropsychologist from Oxford claimed that the smart drug is most effective when the user is faced with a difficult task. The more difficult the task, the better the action of Modafinil.
5. Attention deficit hyperactive disorder
Modafinil has been found to be just as effective in treating the symptoms of ADHD than popular stimulants like Ritalin or Adderall. Also, it is far safer, with fewer side effects and low addictive potential. For this reason, doctors prescribe Modafinil off-label as a treatment for ADHD. Its mechanism of action make it quite gentle with regards to neurotransmitter modulation.
Of course, Modafinil is by no means an antidepressant. Yet studies show that it is effective in treating depression in a different way. Depression causes memory decline, difficulty concentrating and brain fog. This can make it hard for a depressed individual to revert back to normal life, and can even lead to job loss or relapse. Modafinil can help depressed people focus and maintain proper cognition through difficult times.
How does Modafinil work?
Modafinil modulates key neurotransmitters such as dopamine, serotonin, norepinephrine, glutamate, orexin, and GABA. It acts on areas of the brain which increase wakefulness and alertness. It has also been seen to reduce fatigue which in turn keeps you active for longer.
Modafinil decreases uptake of dopamine by inhibiting the dopamine transporter (DAT).
This study concluded that Modafinil increases motivation by inhibition of the DAT.
Some studies hint that Modafinil triggers D2 receptors which secrete dopamine throughout the day.
Modafinil causes serotonin increases in specific areas of the brain. Mainly, serotonin increases in the amygdala, prefrontal cortex and dorsal raphe nucleus.
Modafinil amplifies the action of selective serotonin reuptake inhibitors. This is why Modafinil is also sometimes prescribed with SSRIs such as Prozac.
In an in-vitro study, Modafinil enhanced serotonin discharge from cortical areas. To be noted that it was dependent on the concentration.
This establishes that modafinil modulates cortical serotonin transportation. Also, it works by intensifying the electrical neurosecretion pairing phenomenon. As well as mechanisms other than the reuptake system.
Modafinil also modulates norepinephrine transporters (NET). It increases norepinephrine in the prefrontal cortex and hypothalamus.
One particular study showed that Modafinil amplified vigilance by regulating the NET activity. This is shown by the tomography imaging in vivo.
Glutamate and GABA
The smart drug decreases GABA in the cerebral mantle and in part of the hypothalamus. This study shows its influence on GABA in the thalamus and hippocampus of a rat. The final outcome shows an increase in the release of glutamate in these areas at a dosage of about 100mg/kg. Still, the effect on GABA is quite low. Hence, Modafinil alternates the balance between glutamate and GABA transportation.
Modafinil is seen as a drug for inducing vigilance rather than it’s the curative mechanism. It has been used in cases of attention loss, depression, and mental lethargy. The orexinergic system modulates the wakefulness promoting effects of Modafinil, as stated here.
Modafinil makes use of the symbiotic effect of the orexin mechanism and controls energy use.
How to take Modafinil
The best time to take Modafinil is early in the day, so that you can easily go to sleep at night.
The ideal dose of Modafinil is somewhere between 100mg — 200mg. Doses above 300mg will not lead to extra benefits. In fact, it may lead to the user experiencing side effects such as headaches or agitation.
The effects of Modafinil start within 20–30 minutes and the “peak” lasts well over 6 hours. After that, effects gradually decrease and one does not experience a crash.
Modafinil is regarded as the “world’s first safe smart drug.” Still, it does feature some minor side effects as well. You do not have to worry about it being extremely harmful, as it is approved by the FDA, and it is considered a safe drug. Just like other schedule IV drugs, its potential for abuse is low. Nevertheless, here are some of its side effects that you need to keep in mind:
● Headaches and nausea are common among people who use Modafinil irresponsibly. That means you shouldn’t take Modafinil on an empty stomach. Modafinil can cause headaches due to dehydration or mixing it with other stimulants.
● Dry mouth is common, which is why users are advised to drink more water than usual. Drinking water helps mitigate potential side effects like headaches or dry mouth.
● Difficulties sleeping may occur when taking Modafinil late in the afternoon. Paradoxically, this is a sought-after effect by students who want to study all night. Modafinil does a great job at preventing the user from feeling sleepy. It does so by increasing key excitatory neurotransmitters responsible for the sleep-wake cycle.
● Anxiety may occur at higher doses or when combined with caffeine. This is due to its modulation of norepinephrine, the “fight-or-flight” hormone.
Some of the more extreme but rare side effects include:
● Irregular heartbeat; chest pain or back pain.
● There can be hallucinations and severe depression.
● Confusion and agitation.
If you feel any of these extreme side effects, you must tell your doctor or pharmacist as soon as possible.
Also, don’t forget to talk to your doctor. He is the only one who can give you legitimate advice on anything related to Modafinil. This is a mere review that should act as basic info that you can use to better communicate with your doctor.
Buy Modafinil online or get a prescription for Modafinil?
Well, in an ideal world, anybody can talk to their doctor openly and with good results. Many people are either getting prescribed dangerous stimulants or are misdiagnosed. There are many doctors who either don’t care or don’t want to help. This is why many people prefer to buy Modafinil online. Sure, self-medicating is often frowned upon. Still, there are many who favor experimentation before having a doctor experiment himself. Self experimenting could help cure depression, treat ADHD or be more productive. This can help people lead a happier, more fulfilled life. Modafinil is the best there is when it comes to safe and effective boost in one’s mental capabilities.
The main brand that doctors prescribe is Provigil. Modafinil online is sold as Modalert, Modvigil and Vilafinil. Provigil is 30 US Dollars… yes, you’ve heard right (if you didn’t already know). Online Modafinil generics that are manufactured in India, on the other hand, are available at $0,71 — $2,1. They are just as effective as Provigil, and Modalert is actually approved by the FDA in the US.
You can get a prescription for Modafinil, of course. If you have lots of money to spare, of course. If you’d prefer to spend that money on healthy food, vacations or investments, then you might want to think twice. Funny enough, investment bankers, traders and all sorts of go-getters use it for exactly those reasons. Let’s face it, having money can add years to your life. Thus, it’s safe to say that using Modafinil for cognitive enhancement is a healthy. There is a growing community of users who have made use of Modafinil in the best possible way. Unlike Adderall or Ritalin, it is not habit forming. Nor is it as damaging to one’s body or neurotoxic. On forums such as Reddit, Quora or Longecity, you will see lots of stories. Namely, stories of success in which Modafinil played a key role. You’ll also read of people giving their all to support their families, and that is truly inspiring. Hence, the ethics concerning people buying Modafinil online is highly debatable.
Modafinil is quite a unique substance. It’s reasonable to say that the smart drug is in a league of its own. On one hand, it is a powerful cognitive enhancer. On the other, it has few side effects. As mentioned above, the benefits can greatly outweigh the side effects. Through harm reduction practices and responsible use, side effects can be greatly minimized.
Modafinil is a versatile cognitive enhancer that acts in a variety of ways. The increase in wakefulness, memory retention, focus and motivation are formidable. The cognitive improvements of Modafinil have been a game changer for people worldwide. However, it is a fairly new substance. There are less than 30 years of research conducted on it. The good news is that no serious long-term side effects have been noted. Still, there will always be skeptics, but that is not necessarily a bad thing. Discussion is healthy and constructive. Alas, on a final note, I’d like you to ask yourself these questions:
Would you consider using Modafinil to incite your work ethic or not? Do you think it can pace up your work and make you more efficient? Do you agree with its sale as an off label substance?